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D 5 pts in contrast to part c when an individual

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Unformatted text preview: ubstrate concentration will lead to comparable increases in reaction rate. Page 4 of 6 Name: _______________________________________ Net ID: ______________________ (C) (5 pts) Following intense exercise in an individual who has not eaten any carbohydrate for 24 hrs, the concentrations of the substrates are changed as follows without changes in the Km values of respective enzymes. Substrate Lactate Oxaloacetate Glucose 6 ­phosphate Concentration 600 µM 20 µM 5 µM Enzyme Lactate dehydrogenase Phosphoenolpyruvate carboxykinase (PEPCK) Glucose 6 ­ phosphatase Km 50 µM 20 µM 100 µM Under these conditions, which enzyme is likely to have higher flux control coefficient? Provide a brief explanation. Answer. Lactate dehydrogenase. Substrate concentration far exceeds Km, indicating alcohol dehydrogenase is now the rate ­limiting step. (D) (5 pts) In contrast to part C, when an individual who is well fed with carbohydrate performs intense exercise, the following values were observed: Substrate Lactate Oxaloacetate Glucose 6 ­phosphate Concentration 600 µM 20 µM 500 µM Flux in which metabolic pathway (other than gluconeogenesis) can account for the large increase in liver glucose 6 ­phosphate concentr...
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