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Unformatted text preview: ECG; almost 30% on
echocardiography Due to pressure overload on the heart Involves neuro -hormonal responses of the reninangiotensin system Heart: Left Ventricular Heart: Left Ventricular Hypertrophy ACE inhibitors – block LVH Initially concentric hypertrophy –↑ wall thickness without increase ↑ in cavity volume Adaptive response eventually fails ⇒ dilatation of ventricles and heart failure LVH is an independent risk factor that increases the risk of CVD Regression of LVH may occur with aggressive BP management Heart: Systolic & Diastolic Heart
Dysfunction Systolic Dysfunction Diastolic Dysfunction Reduced LV contractility ⇒ reduced ejection fraction
↑wall thickness ⇒ impaired relaxation ⇒ ↓LV filling May be picked up early on echocardiogram
Both may lead to symptomatic heart failure Heart: Coronary Heart Disease
Heart Hypertension is the largest risk factor for CHD Mechanisms Acceleration of atherosclerosis in the coronary arteries
Impaired endothelial function
Limited coronary flow reserve Manifestations Angina pectoris, acute MI, sudden death Heart: Congestive Heart Failure
Heart State in which the heart is unable to pump enough blood to meet metabolic needs of the body
Hypertension is the major preventable factor in CHF
Due to systolic or diastolic dysfunction or Heart
CHD Kidneys: Chronic Kidney Disease & Kidneys
Renal Failure Arteriosclerotic lesions of afferent & efferent arterioles & glomerular capillary tufts...
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- Winter '14