This generates a futile cycle to burn up atp not a

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: ycle to burn up ATP, not a very healthy situation (See diagram below—the inter- conversion between F6P and F1,6BP takes place all the time [back and forth between them and causes the hydrolysis of ATP each time] ). 4 7. A man heard an explosion nearby and decided to run away from the explosion as fast as he could. His body responded to this shock by releasing a hormone, epinephrine, to the blood stream. The following questions are all related to this condition. a) In response to epinephrine, liver cells released a lot of glucose to the blood stream. Describe the sequence of events from the site of perception of epinephrine to the production of glucose. Events taking place on membranes should be highlighted with an *. Your answer should include name of key enzymes, second messenger, and signaling intermediates. However, NO chemical structures are needed. Epinephrine binds to its receptor (a 7TM receptor) * - Activation of heterotrimeric G-protein * - activated alpha subunit of G-protein activates adenylyl cyclase * - [cAMP] increases -- cAMP inactivates glycogen synthase, but activates protein kinase A - Activated protein kinase A activates glycogen phosphorylase kinase - glycogen phosphorylase is activated - hydrolysis of glycogen (to generate G-1-P that is converted) to glucose - glucose secreted to the blood stream b) Glucose produced by liver was then transported to muscle to support the running this man was doing. Describe how glucose is metabolized to generate the ATP needed when there was plenty of oxygen. Your answer should include 1) names of pathways involved, 2) number of carbon atoms in key intermediates, and 3) cellular locations for each pathway. However, NO need for names of enzymes and chemical structures. 1. Glycolysis in cytosol: C6 (glucose) C3 (glyceraldehydes) C3 Pyruvate 2. Pyruvate oxidation in matrix of mitochondria C3 pyruvate C2 acetyl CoA 3. Citric acid cycle (CAC) [Krebs cycle or TCA cycle OK] in matrix of mictochodria C2 acetyle CoA + C4 C6 citric acid C5 + CO2 C4 + CO2 4. e transport and oxidative phospho...
View Full Document

Ask a homework question - tutors are online