MIMM324_Phage_I

Current research into bacteriophage model organism

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Unformatted text preview: s are made of DNA (Hershey & Chase experiment, 1952) •  Virus ­mediated gene transfer between cells (Zinder 1953) •  RestricGon and modificaGon (Bertani & Weigle, 1953) •  Co ­linearity of gene and protein (Benzer, 1959) •  The nature of the geneGc code (Crick, Barnep, Brenner, & Waps ­Tobin, 1961) •  Physical nature of geneGc recombinaGon (Meselson & Weigle 1961) Are Bacteriophage still relevant? •  Current Research into bacteriophage •  Model Organism •  Phage Therapy •  Phage Display •  SyntheGc Biology •  Nano ­materials •  CRISPER’s •  Industrial FermentaGon Failure •  Biotechnology Industry •  Dairy Industry Structure and Function of Bacteriophage •  All bacteriophage in these talks infect E.coli •  dsDNA Tailed Phage •  Podoviridae  ­ T7 •  Siphoviridae – Lambda •  ssRNA phage •  Microviridae  ­ φX174 •  ssDNA phage •  Levivirdae  ­ MS2 •  Inoviridae (filamentous phage) – f1, fd, M13 dsDNA Tailed Phage •  Large Head •  Icosahedral or Prolate •  Tail •  Short or Long •  ContracGle or Non...
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