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MIMM324_human disease_2013

MIMM324_human disease_2013 - Leading Infec,ous Diseases DNA...

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Leading Infec,ous Diseases
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DNA Viruses Herpesviridae
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Latent vs Ly,c Infec,on
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dsRNA Viruses
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Deadly Viruses
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Influenza Spanish Flue 1918
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Approved Reverse Transcriptase Inhibitors Preferred or alterna,ve combina,ons 3 drugs± single dose± once daily
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HCV DrAG ResisSS 2012 v.1 26 www.hivforum.org Unlike HIV and HBV, HCV is curable Virus HIV HBV HCV Genome RNA DNA RNA Mutation Rates Very High High Very High Virions Produced Daily 10 10 10 13 10 12 Long-lived proviral reservoir YES YES NO Viral Targets of Therapy Multiple One Multiple Cure With Current Therapy? NO (Integrated viral DNA) NO (cccDNA) YES Current Therapeutic Goal Lifelong suppression Lifelong suppression Cure
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MIMM324_human disease_2013 - Leading Infec,ous Diseases DNA...

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