Not clear if smallpox vaccine protects molluscum

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Unformatted text preview: local skin lesion; rare zoonosis Yabapox local skin lesion; rare accidental infec:on molluscum contagiosum Mul:ple skin lesions; human transmission Parapoxviruses Yatapoxvirus Molluscipoxvirus The Smallpox Vaccine Monkeypox Mostly confined to Africa but there was an outbreak in the US of 100 cases in 2003. Not clear if smallpox vaccine protects. Molluscum Contagiousum In the US it accounts for 1% of all diagnosed skin condiMons. Spreads by physical contact. ALL poxviruses replicate in the cytoplasm L C L E Poxvirus Genome Poxvirus Gene Nomenclature Hind III Size (kbp) genes e.g. O2L There are approximately 250 open reading frames Poxvirus ReplicaMon Poxvirus ReplicaMon Poxvirus Gene Expression “Cascade” GeneMc Program All enzymes and factors required for early Gene expression are packaged with the virus. Early mRNAs encode enzymes for viral DNA synthesis and factors for expression of the intermediate class of genes. Intermediate genes encode factors for expression of the late class of genes. Late transcripMon transcripMon factors acMvate the enzymes and factors required for early gene expression. Poxvirus ReplicaMon Poxvirus DNA ReplicaMon “self” priming Poxvirus ReplicaMon Poxvirus ReplicaMon Poxvirus ReplicaMon Poxvirus ReplicaMon Poxvirus ReplicaMon Poxvirus ReplicaMon Poxvirus encoded “Viroceptors” Virus Open reading frame Func9on Myxoma virus M- T1 secreted CC- chemokine binding protein Myxoma virus M- T7 secreted IFN- gamma receptor homologue and CC- ,CXC- , C- chemokine binding protein Myxoma virus M- T2 secreted TNF receptor homologue Vaccinia virus B15R secreted IL- 1b receptor homologue Vaccinia virus B18R secreted IFNalpha/beta binding protein CreaMon of Vaccinia Virus Expression Vectors...
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