Poxvirus III Polyomavirus Lecture 13

Iii digestion map a b c d e f g h i j k source danna

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Unformatted text preview: tiates Replication • Binds viral DNA at the origin of replication • Has Helicase activity • Forms complexes with several cellular DNA replication proteins including DNA polymerase αprimase, Polyomaviruses Genome Hind III Digestion Map A B C D E F G H I J K Source: Danna & Nathans, PNAS (69) 3097-3100 (1972) Poulin & DeCaprio, J. Clinical Oncology 24 (26) 4356-4365 (2006) Mapping the Origin of Replication Replicating Molecules Completed Molecules 0 Min 3H dT 5 Min 15 Min Source: Danna & Nathans, PNAS (69) 3097-3100 (1972) Mapping the Origin of Replication Source: Danna & Nathans, PNAS (69) 3097-3100 (1972) Polyomavirus Replicative Cycle Attachment and Entry Early Late ? ? ? Nucleus Major Histocompatibility Complex? RNA Pol II Large T Small T Large T VP1 VP2 VP3...
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This document was uploaded on 01/26/2014.

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