Poxvirus III Polyomavirus Lecture 13

Poxvirus III Polyomavirus Lecture 13 - DNA Viruses Poxvirus...

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DNA Viruses – Poxvirus III/Polyomavirus Brian M. Ward February 8, 2013 MBI 456
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Insertion of Genes Under T7 Control
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Fusion From Within Assay DNA Phase pH 7.4 +A28 pH 5.5 pH 7.4 -A28 pH 5.5
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Fusion From Without Assay DNA Phase pH 7.4 +A28 pH 5.5 -A28 Merged
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Outer EEV Envelope Nonfusogenic Viral Membrane Dissolution The addition of glycosaminoglycans exposes IMV antigens on EEV Law, Mansun et al. (2006) Proc. Natl. Acad. Sci. USA 103, 5989-5994 IMV
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Poxviruses Encode Interferon Decoys B18 B8
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Smallpox Infection Prolonged face-to-face or direct contact with contaminated objects. 12-14 day incubation period followed by initial symptoms lasting 2-4 days and include:high fever, malaise, head and body aches and sometimes vomiting. Initial symptoms followed by pustular rash lasting ~5 days. Pustules are sharply raised bumps firm to the touch. Pustules begin to scab over and fall off (~10 days).
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Family Poxviridae Moss, B. 2001. Poxviridae : The viruses and their replication, p. 2849-2883. In B. N. Fields, D. M. Knipe, and P. M. Howley (ed.), Fields Virology, Fourth ed, vol. 2. Lippincott-Raven Publishers, Philadelphia.
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Poxviruses that Infect Humans Orthopoxvirus variola (major & minor) monkeypox cowpox camelpox vaccinia Yatapoxvirus Yaba monkey tumor virus tanapox Parapoxvirus pseudocowpox, orf Molluscipoxvirus molluscum contagiosum
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Monkeypox • First Human case reported in the Democratic Republic of Congo in 1970 • Human to human transmission is rare but does occur • Caused by a member of the Orthopox genus
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Poxvirus III Polyomavirus Lecture 13 - DNA Viruses Poxvirus...

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