Proportion of polymorphic loci in popn 2 to 4 small

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Unformatted text preview: ng during times of low N and Ne further reduced both N and Ne • Proportion of polymorphic loci in pop’n = 2% to 4% SMALL! • Proportion of heterozygous loci per individual animals.nationalgeographic.com • In captive cheetahs: = 0.04% to 1.4% SMALLER! • MHC locus: • Disease and MHC symptoms suggest an interactive effect of loss genetic diversity and threats to population persistence BUT….. (not true) – Striking lack of variation – Captive cheetahs do not reject skin grafts from others •Low sperm counts •High disease load 9 -This suggests that inbreeding depression is damaging the ability to reproduce 10 -The MHC locus is not working well to recognize foreign objects -Cheetahs in the captive popln are not greatly genetically different, t herefore the skin graft from another cheetah is not recognized as f oreign (and it is accepted) The Complications Conclusions • Dead cheetahs from wild Namibian populations: – No signs of disease, high viral load, or infectious disease induced mortality • ~75% of mortality of cubs is due to predation when mother is hunting • Genetic diversity does not appear to affect cheetah disease susceptibility or demography in the wild • Depending on how one estimates genetic diversity… – Low genetic variability unlikely to affect such predation effects • Refined genetic diversity estimates: – MHC allele number: low compared to other mammals – Nucleotide diversity: similar to other cats, high compared to dogs ...
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