Creatine Supplementation

However when the cr group was divided into responders

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Unformatted text preview: p was divided into responders and nonresponders based on estimated intramuscular Cr storage after loading, peak isometric force and total force production was significantly higher than the placebo group. It was reported that Cr uptake was inversely proportional to training status (r = –0.68) suggesting that less-trained individuals uptake Cr more readily than more highly trained individuals.[38] This could be due to the near saturation of intramuscular Cr stores seen in highly trained individuals, probably through ingesting increased amounts of dietary protein in the form of red meat. Less-trained individuals may not actively seek to increase protein intake and, therefore, may have lower levels of saturation before Cr supplementation. Additionally, higher intramuscular Cr stores may also be a physiological adaptation to highintensity resistance training. It should be noted that by partitioning the Cr group into responders and non-responders, a very different data interpretation resulted and, as such, this method may be considered biased reporting of the data and should be viewed accordingly. 2.1.4 Eccentric Induced Muscle Soreness/Damage Eccentric action induces muscle soreness and damage at both the sarcolemmal and sarcoplasmic reticular membranes.[59,60] A change in sarcoplasmic reticulum activity can lead to an increase in proteolytic enzymes, ultimately leading to contractile protein degradation.[61] PCr has been associated with 2005 Adis Data Information BV. All rights reserved. membrane stabilisation[62] leading to the notion that Cr supplementation may help lessen the degenerative effects of eccentrically induced muscle damage. In one of the few published articles in this area, Rawson et al.[11] investigated the effects of Cr supplementation on eccentrically induced muscle damage. Twenty-three men aged between 18 and 36 years were randomly assigned to either a Cr (n = 12; 20 g/day for 5 days) or placebo group (n = 11). Fifty maximal eccentric contractions of the elbow flexors were used to induce muscle damage and elbow flexor MVC, elbow range of motion, blood creatine kinase, lactate dehydrogenase, distal arm circumference, and soreness with movement and palpation were assessed. There were no significant...
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