Exercise 1_KEY_Final_4Feb

Do not take antibiotics for viruses or unnecessarily

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Unformatted text preview: se is to not let bacterial resistance evolve in the first place – the most common approach is to develop new antibiotics and use them before resistance can evolve. But we are in an evolutionary arms race with pathogens. Do not take antibiotics for viruses or unnecessarily. All of the anti ­bacterial strategies can lead to evolution of resistance. 4) A mutation has occurred in a DNA sequence in A yielding the DNA sequence in B (4 points). A. ATT CCG GGG TTT AAA GCC CAA B. ACT CCG GGG TTT AAA GCC CAA Directly transcribe the DNA sequence in A and B to RNA. Translate each of these sequences to the amino acid sequence, report in which codon the mutation is found and whether a transition, transversion, insertion or deletion, at what position it occurred (1st, 2nd, 3rd), if the mutation is a synonymous or non ­synonymous change. Because we were unclear with whether this was the coding or the template strand, we accepted multiple answers: A. AUU CCG GGG UUU AAA GCC CAA Isoleucine Proline Glycine Phenylalanine Lysine Alanine Glutatmine B. AGU CCG GGG UUU AAA GCC CAA Serine Proline Glycine Phenylalanine Lysine Alanine Glutatmine The mutation is in the 1stth codon, second position, is a point mutation in the DNA strand of T to a C, a non ­synonymous one and is a transition and results in an amino acid substitution from isoleucine...
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This note was uploaded on 02/02/2014 for the course ECOL 335 taught by Professor Reinthal during the Spring '10 term at University of Arizona- Tucson.

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