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Unformatted text preview: cted in 1950 and 2000. Assume the entire genome is evolving
under neutral expectations.
a. What is mutation rate on a per-replication and per year basis in the virus (include
2,000 mutations/50 years = 40 mutations/year
2,000 mutations/50 years*10,000 generations/year = 0.004 mutations/replication
b. You find a vial that you know was collected prior to 1950, but you do not know the
exact year. Assume that the virus always has the same mutation rate. You sequence the
genome of this virus and find 10,000 single base pair differences between the sample
collected in 1950 an this sample that was collected at the unknown time. When do you
estimate this sample was collected and why?
10,000 mutations/40 mutations/year = the year 1700, given the same mutation rate,
10,000 mutations must have accumulated over this interval.
6. You are in charge of estimating the effective number of migrants between two desert
pupfish populations. Great Basin National Park is asking you to determine if two
different springs containing pupfish are one or two distinct populations. They define
distinct as less than one migrant per generation. You genotype 20 individuals of each
population at 10 variable microsatellite loci (each locus has multiple allele...
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