Exercise 3_KEY_FINAL_2013_6FEb

Assume the entire genome is evolving under neutral

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Unformatted text preview: cted in 1950 and 2000. Assume the entire genome is evolving under neutral expectations. a. What is mutation rate on a per-replication and per year basis in the virus (include units)? 2,000 mutations/50 years = 40 mutations/year 2,000 mutations/50 years*10,000 generations/year = 0.004 mutations/replication b. You find a vial that you know was collected prior to 1950, but you do not know the exact year. Assume that the virus always has the same mutation rate. You sequence the genome of this virus and find 10,000 single base pair differences between the sample collected in 1950 an this sample that was collected at the unknown time. When do you estimate this sample was collected and why? 10,000 mutations/40 mutations/year = the year 1700, given the same mutation rate, 10,000 mutations must have accumulated over this interval. 6. You are in charge of estimating the effective number of migrants between two desert pupfish populations. Great Basin National Park is asking you to determine if two different springs containing pupfish are one or two distinct populations. They define distinct as less than one migrant per generation. You genotype 20 individuals of each population at 10 variable microsatellite loci (each locus has multiple allele...
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