February_6_2013_NKW

# How would you esmate the divergence me given a 0001

This preview shows page 1. Sign up to view the full content.

This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: human 0.012 changes/site/12 million years 6 Mya 1.2% 0.001 subs11ons/site/million year chimp NEUTRAL THEORY Divergence time •  This equation might allow you to calculate divergence times between lineages more quickly : •  t = D/2u •  t = time since divergence from a common ancestor •  D = number of base pair differences between two sequences. •  u = neutral mutation rate 5 Human ­chimp sequence divergence on diﬀerent chromosomes (sequence is largely non ­coding) 2. How would you es?mate the divergence ?me given a 0.001 subs?tu?ons/site/ million years and average 1.2% divergence between chimps and humans? divergence 1me=? human ? Mya 1.2% chimp t= Long ­term Ne in human is es1mated to be ~10,000 to 20,000. As of today, the human popula1on is es1mated by the US Census Bureau to be 7, 064,088,716 humans Use: t = D/2u t= Measures of varia?on c...
View Full Document

## This note was uploaded on 02/02/2014 for the course ECOL 335 taught by Professor Reinthal during the Spring '10 term at University of Arizona- Tucson.

Ask a homework question - tutors are online