February_6_2013_NKW

What is the best explanaon for the dierences in

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Unformatted text preview: Deleterious--------------neutral---------Beneficial (s) 2. How would you es1mate the muta1on rate from this average 1.2% divergence between chimps and humans? NEUTRAL THEORY American Journal of Human Gene1cs 2002 70:1490 4 Human ­chimp sequence divergence on different chromosomes (sequence is largely non ­coding) 1.  What is the best explana?on for the differences in divergence on X and Y compared to autosomes?  ­Y chromosome occurs only in males, undergoes more replica1ons per unit 1me. Thus, higher muta1on rate per unit 1me compared to autosomes Male ­Biased Muta1on  ­X chromosome occurs mostly in females (2/3 are in females in any one genera1on), thus has a lower average muta1on rate per unit 1me compared to autosomes. 2. How would you es?mate the muta?on rate from this average 1.2% divergence between chimps and humans? since K=u (subs1tu1on rate=muta1on rate) divergence 1me=6 million years (fossils)...
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This note was uploaded on 02/02/2014 for the course ECOL 335 taught by Professor Reinthal during the Spring '10 term at Arizona.

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