February_6_2013_NKW

What is the mean time to xation for a new neutral

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Unformatted text preview: vergence between two alleles or the proportion of nucleotide sites at which two alleles randomly drawn from the population differ ! $ n 'L " =& )* (2 piqi ) L = ( 4 / 3)[(17)(0) + (2)(0.5) + (1)(.375)] / 20 = 0.0917 % n # 1( i=1 % ( ' * 1* " = S / L' n #1 = 3 / 20(1 /1.833) = 0.0818 ' * ' $1 / i * & i=1 ) What is the standard error of these estimates? Recall that standard error = √Var" 68% of estimates lie within one standard error" 95% of estimates lie within two standard errors" ! 99.7% of estimates lie within three standard errors" " Assignment: calculate 95% confidence intervals for these estimates of nucleotide variability" 8 Three equations to know from Neutral Theory 1. What is the mean time to fixation for a new NEUTRAL mutation? t = 4Ne generations (diploids) also = coalescence time (how far back for all modern copies to trace to a single ancestral copy) 2. What is the rate of molecular evolution? (what is the rate of substitu...
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