Adult respiratory distress syndrome.pptx - Adult...

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Adult respiratory distress syndrome Dr. Wangari Wambugu
Outline Introduction Pathophysiology of ARDS Pathology of ARDS Gross features Microscopic features ARDS vs infant respiratory distress ARDS vs heart failure lung Investigations
Introduction ARDS is also known as
DEFINITION Refers to Severe Acute Lung Injury (ALI) ALI also called noncardiogenic pulmonary edema) is characterized by the abrupt onset of significant hypoxemia and diffuse pulmonary infiltrates. Histologically there is diffuse alveolar capillary damage. (DAD)
Introduction A clinical syndrome caused by diffuse alveolar capillary damage. Characterised clinically by the rapid onset of severe life threatening respiratory insufficiency, cyanosis, and arterial hypoxemia. Refractory to O 2 therapy, may progress to extra pulmonary multisystem organ failure.
Clinical disorders associated with development of ARDS Direct lung injury Aspiration pneumonia* Diffuse pulmonary infections* Viral, miliary TB, Mycoplasma and Pneumocystis pneumonia Inhalation injury O 2 toxicity, smoke, gases Pulmonary contusions Fat emboli Reperfusion injury Near drowning Indirect lung injury Sepsis* Severe trauma* Shock Acute pancreatitis Cardiopulmonary bypass TRALI DIC Severe burns Head injury Drug overdose Heroin and barbiturate overdose,aspirin * More than 50% of cases of ARDS associated with these
ARDS pathogenesis

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