Lecture 6 More on Proteins the enzymes

Lecture 6 More on Proteins the enzymes - Lecture 6...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
Lecture 6 Molecular Chaperones Different classes Prions Prion Theory Possible mechanism Proteomics, Protein engineering Enzymes Basic properties Active Site
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Points of the day Chaperones are necessary to protect hydrophobic surfaces from interacting inappropriately Misfolding of proteins can lead to disease
Background image of page 2
Quaternary Structure Proteins with multiple subunits Same forces as tertiary (H-bonding, etc.) Problem: Hydrophobic interactions 0
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Molecular Chaperones Proteins which interact with non-native (unfolded) proteins Cover exposed hydrophobic surfaces Facilitate protein folding or maintain unfolded form (mitochondrial import) Heat shock proteins 0
Background image of page 4
Two Families of Chaperones HSP = heat shock proteins HSP 70 family promote unfolding, HSP 60 site of folding 0
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
When Protein Folding Goes Awry “The Human perspective” pp 65-68 A number of spongiform encephalopathies Scrapie (sheep) Kuru in Papua, New Guinea Mad Cow Creutzfeld-Jakob (CJD): either inherited or infectious 0
Background image of page 6
PrP C and PrC Sc 0
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 26

Lecture 6 More on Proteins the enzymes - Lecture 6...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online