January 13, 2014

Current opinion in neurology 254410 420 august 2012

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Unformatted text preview: formed with functional MRI; SPECT, single-photon emission computed tomography. Current Opinion in Neurology. 25(4):410-420, August 2012. Amyloid-binding molecules are used in PET to follow progression of AD Expensive compound to make Top HC ( more AB deposit ) blue /barely any healthy subject Bottom AD / patient with AB deposits Compare healthy and disease brains How disease is progressing Radio-labeled molecules used in PET to study biological mechanisms affected in disease Potential for the development of imaging techniques for early diagnosis in AD Microglial activation Bind to activated microglial Progression of it . early on or later occurrence how can we effect that ? PET scan mostly AD Curr Opin Neurol 2012, 25:410–420 PET scan in Parkinson’s disease We want to see more activation in PD, decrease in Activation Healthy control lots of red. These neurons become activated. By using PET scan.Activation within brain, restored by drug. PET analysis. http://www.parkinson.org PET analysis to follow PD progression You get decrease in normal activation. Text PET analysis to evaluate neuronal integrity and functionality we lose neurons within cortical areas. neurons are using glucose. Blue showing neurons not functional. MRI analysis in Huntington’s disease Prion Disease Lots of cortical degeneration/ Jakob disease/ MRI shows progressive cortical degeneration in Prion disease July November Progression of cortical degeneratio n in few months , anterior cortical degeneratio n MRI in amyotrophic lateral sclerosis Normal control at the bottom ALS = losing motor neurons in brain/ MRI used Normal ALS MRI in multiple sclerosis MRI in MS patients, MRI with white matter different points, subcortical regions Image courtesy of Siemens Medical Solutions. Need new diagnostic tools Development of early and specific diagnostic approaches is crucial to impact the success of a therapy for neurodegenerative diseases we need to find new ways to diagnose these neurodegenerative diseases so we can gain insights and find new therapies. Study the BIOLOGY of these diseases to unravel the mechanisms that are responsible for the disease...
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