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Unformatted text preview: formed with
functional MRI; SPECT, single-photon emission computed tomography.
Current Opinion in Neurology. 25(4):410-420, August 2012. Amyloid-binding molecules are used in PET to
follow progression of AD Expensive compound to make
Top HC ( more AB deposit ) blue /barely any
Bottom AD / patient with AB deposits
Compare healthy and disease brains
How disease is progressing Radio-labeled molecules used in PET to study
biological mechanisms affected in disease
Potential for the development of
imaging techniques for early
diagnosis in AD
Bind to activated microglial
Progression of it . early on or later occurrence
how can we effect that ?
PET scan mostly AD Curr Opin Neurol 2012, 25:410–420 PET scan in Parkinson’s disease We want to see
more activation in
PD, decrease in
control lots of red.
By using PET
restored by drug.
PET analysis. http://www.parkinson.org PET analysis to follow PD progression
You get decrease in normal
activation. Text PET analysis to evaluate neuronal
integrity and functionality
we lose neurons
functional. MRI analysis in Huntington’s disease Prion Disease
disease/ MRI shows progressive cortical degeneration
in Prion disease
n in few
n MRI in amyotrophic lateral sclerosis
Normal control at the bottom
ALS = losing motor neurons in
brain/ MRI used Normal ALS MRI in multiple sclerosis
MRI in MS patients,
MRI with white
regions Image courtesy of Siemens Medical Solutions. Need new diagnostic tools
Development of early and specific diagnostic approaches is crucial to
impact the success of a therapy for neurodegenerative diseases
we need to ﬁnd new ways to
diagnose these neurodegenerative
diseases so we can gain insights
and ﬁnd new therapies. Study the BIOLOGY of these diseases to unravel the
mechanisms that are responsible for the disease...
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- Winter '14