January 13, 2014

Cell death h contain cell death d and als meant to

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Unformatted text preview: uclear fragmentation, cytoplasmic blebbing • Caspases have been implicated in the death of neurons that occurs in AD, PD, Program cell death H contain cell death D and ALS Meant to happen in series of step Traumatic type of cell death Increase extracellular Glutumate / intracellular CA / Nitric oxide ..all lead to cell death we have system to survive /gettin rid of the bad guys. Death of neurons/ ALS, PD and ALS increase in apoptosis Cytochocrome C big player (initiate cell death Common features - Cell death • Necrotic cell death Text Text • Characterized by cell and organelle swelling or rupture of Text cell membranes accompanied by spillage of intracellular contents • Usually considered to be an accidental form of cell death and is commonly observed after trauma or infection Text Text • Reported in Parkinson’s, Alzheimer’s, and Huntington’s diseases, and in amyotrophic lateral sclerosis www.vce.bioninja.com.au Common features - Cell death • Apoptosis versus Necrosis contain cell death apoptosis / necrosis bigger and bigger and then rupture and releases everything/ inflammation ( we want to contain that) Controlled cell death www.celldeath.de Common features - Cell death Text • Autophagic cell death • Process where cells break down out-dated and damaged cellular organelles and proteins to be replaced with new ones. • Survival mechanism providing cells with energy and substrates for cellular processes in times of stress and starvation. • There is a growing awareness of a possible role for autophagy NDD. We gonna replace them, we gonna get rid of old one first, membrane formation engulf damaged organelle, close it and breaks it down. provides cell with energy. http://www.nexcelom.com/Nexcelom-Blog/autophagy/#more-566 Common Features - Protein misfolding and aggregation • Amyloid:Text myloid fibrils are filamentous, hydrophobic a Text structures, width ~10nm, length between 0.1kind of fibrils are common to different neurodegenerative diseases, from Alzheimer’s to Huntington’s disease. NH2 COOH Nat Med....
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This document was uploaded on 02/03/2014.

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