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Unformatted text preview: uclear fragmentation, cytoplasmic blebbing
• Caspases have been implicated in
the death of
occurs in AD, PD,
Program cell death
contain cell death D and ALS
Meant to happen in series of step
Traumatic type of cell death
Increase extracellular Glutumate /
intracellular CA / Nitric oxide ..all lead
to cell death we have system to
survive /gettin rid of the bad guys.
Death of neurons/ ALS, PD and ALS
increase in apoptosis
Cytochocrome C big player (initiate
cell death Common features - Cell death
• Necrotic cell death
• Characterized by cell and organelle swelling or rupture of
Text cell membranes accompanied by spillage of intracellular
• Usually considered to be an accidental form of cell death
and is commonly observed after trauma or infection
• Reported in Parkinson’s, Alzheimer’s, and Huntington’s
diseases, and in amyotrophic lateral sclerosis www.vce.bioninja.com.au Common features - Cell death
• Apoptosis versus Necrosis contain cell death apoptosis / necrosis
bigger and bigger and
then rupture and
inﬂammation ( we want
to contain that)
Controlled cell death www.celldeath.de Common features - Cell death
• Autophagic cell death
• Process where cells break down out-dated and damaged
cellular organelles and proteins to be replaced with new ones.
• Survival mechanism providing cells with energy and
substrates for cellular processes in times of stress and
• There is a growing awareness of a possible role for
autophagy NDD. We gonna replace them, we
gonna get rid of old one ﬁrst,
membrane formation engulf
damaged organelle, close it
and breaks it down. provides
cell with energy. http://www.nexcelom.com/Nexcelom-Blog/autophagy/#more-566 Common Features - Protein misfolding
• Amyloid:Text myloid fibrils are filamentous, hydrophobic
Text structures, width ~10nm, length between 0.1kind of fibrils are common to different neurodegenerative
diseases, from Alzheimer’s to Huntington’s disease.
NH2 COOH Nat Med....
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This document was uploaded on 02/03/2014.
- Winter '14