Carleton-Lecture-Animal models stroke and VaD

2002 jcbfm cognijve assessments in animal models

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Unformatted text preview: Chen et al., 2013, Neur Regen Res Stroke and VaD •  Stroke and Vascular demenJa (VaD) share common risk factors •  Both result from abnormaliJes in cerebrovascular perfusion •  Metabolic disturbance that leads to neuronal death •  There is a link between stroke and VaD •  Not surprising that animal models of stroke are also used to study VaD Models of VaD •  Focal hypoperfusion –  MCAo (rats and mice) –  ET- 1 injecJon •  Global hypoperfusion- transient –  Rat 4VO –  Mouse and gerbil 2VO •  Global hypoperfusion- chronic –  Bilateral common caroJd artery occlusion in the rat (BCCAo) –  Bilateral caroJd stenosis in the mouse and gerbil Bilateral CCA stenosis (BCAS) •  Surgical narrowing of both CCA •  Microcoil made out of piano wire is twined by rotaJng it around the CCA •  The reduces blood flow Ihara and Tomimoto (2011), J. Aging Research Bilateral CCA stenosis (BCAS) Ihara and Tomimoto (2011), J. Aging Research bilateral CCA stenosis in mice (BCAS) Blood flow reducJon varies depending of internal diameter of wire Cerebral blood flow aher BCAS. This figure shows cerebral blood flow evaluated with laser Doppler flowmetry in mice at 2.5 months of age aher the surgery using microcoils with diameter of 0.16 mm, 0.18 mm, 0.20 mm, and 0.22 mm. The data represent mean values expressed as a percentage of the preoperaJve valu...
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