Carleton-Lecture-Animal models stroke and VaD

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Unformatted text preview: ng hematoma size at 24 hr aher intrastriatal injecJon of bacterial collagenase (0.075 U). LH=leh hemisphere, RH=right hemisphere. J. Vis. Exp. 2012 (67) e4289 Hemorrhagic stroke models:ICH NeurofuncJonal assessments following experimental ICH in mice. Intrastriatal injecJon of autologous blood (30 μl) or bacterial collagenase (0.075 U) caused reproducible neurofuncJonal deficits. (A) Mice aher experimental ICH showed significantly more right turns than sham operated animals at 24 and 72 hr aher surgery. (B) Forepaw placing capacity of the leh limb was impaired aher ICH at 24 and 72 hr aher surgery. J. Vis. Exp. 2012 (67) e4289 Hemorrhagic stroke models: SAH •  Majority (~80%) are caused by rupturing of intracranial aneurysms located along the anterior and posterior communicaJng artery, basilar artery and the middle cerebral artery •  Aneurysms are difficult to model in animals •  Animal models of SAH: –  InjecJon of blood into the subarachnoid space –  Endovascular perforaJon of a subarachnoid vessel Hemorrhagic stroke models: SAH •  A monofilament suture sharpened at one end is introduced through the external caroJd artery (eca) •  It is advanced through the intracranial internal caroJd artery (ica), penetraJng near the bifurcaJon. •  Withdrawal of the suture results in subarachnoid hemorrhage. Bederson et al., 1995 Stroke Hemorrhagic stroke models: SAH Normal SAH 1 day 3 days Brain specimens of subarachnoid hemorrhage (SAH) rats....
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