BIO 102 Unit 4 Part 2_ Cytoskeleton Notes

In drugs cytochalasins bind barbedplus ends inhibits

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Unformatted text preview: the most ADP subunits A ct in drugs: * cytochalasins: bind barbed/plus ends, inhibits polymer ization * latrunculin: binds monomers and inhibits polymer ization, will induce depolymerization * phalloidin/jasplakinolide: bind and stabilize filaments. phalloidin can be labeled with fluor escent dyes, making it useful for staining actin filaments in cells [lowers crit concentration of any given filament[ jas. is cell per meable and can be used on live cells Ov erv iew of funct ional classes of act in binding prot eins 1. Monomer binding/sequestration pr oteins: beta thymosin (shifts equilibrium to depolymerization - little blue thing sticks onto the r ed and allows it to depolymerize) 2. profilin: promotes nucleotide exchange on G-actin, directs preferntial subunit addition onto plus end of growing actin filament capping proteins: either bind to plus or minus end 3. plus/bar bed end capping proteins: pr event both subunit loss and addition at plus end and r aise the critical concentration to that of the minus end * many plus end cappers...
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This note was uploaded on 02/05/2014 for the course BIO 102 taught by Professor Chandhoke during the Fall '13 term at Yale.

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