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Unformatted text preview: Null mutation: no LDL surface binding, no internalization
2. Mutated ligand binding domain; no LDL binding or internalization receptor localizes to coated
pits; cycles thr ough endosome--> cell surface
3. T runcated cytoplasmic domain: Cell surface binding of LDL; no internalization
4. S top codon mutation befor e transmembr ane domain: no binding no inter nalization; receptor is
5. Ty rosine- - > Xmut at ion in cy t oplasmic domain; normal surface binding; no
recruit ment t o coat ed pit s; no int ernalizat ion (truncated, missing tyr osine altogether. 3 is
truncated also but missing a ledge altogether)
^ Draw w hat each curve would look like...
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This note was uploaded on 02/05/2014 for the course BIO 102 taught by Professor Chandhoke during the Fall '13 term at Yale.
- Fall '13