Lecture 23 Endocytosis then Cytoskeleton

Lecture 23 Endocytosis then Cytoskeleton - Lecture 23...

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Lecture 23 Lysosomes Targeting of proteins Role in organelle turnover Endocytosis Different types Receptor mediated Phagocytosis Cytoskeleton General aspects Microtubules
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Announcements TAs will hold review session for lab on Friday in lab beginning at 3 pm. This is to help prepare for lab final Changes in syllabus: Monday next week: Cellular reproduction. Chapter 14, pgs 570-579 Wednesday and Friday, Chapter 15 on Cell- cell signaling Omit Chapter 17 on Immunology
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Main Points Lysosomal proteins are targeted via signal added during maturation in Golgi Endocytosis can balance amount of membrane on cell surface and can also bring in needed materials for the cell Three major classes of cytoskeletal elements each have their own structure and roles
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Synthesis begins on free ribosomes. When signal sequence is made, SRP recognizes it and everything goes to the ER Protein is inserted into the ER through the translocon. Signal sequence is cleaved off. As Asn residues are incorporated into the protein, 14 sugar oligosaccharide chain is transferred to the protein Within ER, disulfide bonds form due to oxidizing environment. Proteins are folded with aid of chaperones (e.g. BiP)
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Lecture 23 Endocytosis then Cytoskeleton - Lecture 23...

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