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Blood_2012 - 20 0.$3 45$#$)6$ $/01$...

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! !"# %%&' () (*+ ,-./01 20+0)*. 3+45 ()6 (*+ ,-./01 7*)895:*;<-.*) =1;>0? @1?AB*>9< =1;>0? C0;A9)*>5)1 =1;>0? ()6 D9++9*+ 7B0+ (9E0;>9:0 =1;>0? ,0>*F5.9;? C0+*. =1;>0? G<98H#*;0 I5?05;>*;9; C0A)58-<>9:0 =1;>0?
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" #$% '$()*+,$( - .. % . / 0 1 - 2 3 . .. 4 -5..6%*(7 .$,/*+$ 0 1869 -,2$3*.$ 6( :$.. 6( .$,/*+$ ;;/< :=.. %$ ;)(/$3 )> ?*(@5AB< 4 1869 6>3 .6% C+63$( :=.. %$ ;)(/$3 )> ?*(@5AB
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D 20+0)*. 3+45)?*>95+J ()6 ,-./01 K8*+90.6?-./01L-<5++608- M 5449<0 [email protected]= O%% KPQRH'&SSM 5449<0 B5-);J NTNB UJVSHOSJVS*? .0<>-)0 NGJ (*))0+ I*))9;5+ K8*))0+6B*))9;5+L-<5++608-M N0W>J I-?*+ !B1;95.5E1J *+ 9+>0E)*>08 *AA)5*<B ' >B 089>95+ H 15- *)0 )0;A5+;9F.0 45) *.. ?*>0)9*. <5:0)08 9+ .0<>-)0 <5:0)08 9+ .0<>-)06 @*FJ ;>*)>; +0W> X00/ G<*80?9< I5+5) 7580
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E 7*)895:*;<-.*) =1;>0? K0W*? 3M . 36 #.558 336 I0*)> 3336 79)<-.*>95+
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F #.558 20+0)*. Y->.9+0J 36 #.558 <5?A5;9>95+ 336 C08 F.558 <0.. K0)1>B)5<1>0M ;>)-<>-)0T4-+<>95+ 0)1>B)5A59;9; F.558 >1A0 3336 ZB9>0 F.558 <0.. K.0-/5<1>0M 4-+<>95+*. >1A0; A)58-<>95+
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G 3[6 !.*>0.0>; 4 >9 Y->.9+0 75+>9+-086 4-+<>95+ A)58-<>95+ B0?5;>*;9;
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H =B5)> .9;> 54 <5??5+.1 -;08 ?089<*. A)049WT;-449W 8049+9>95+; suffix meaning I35>=6 ;6=>7 (:$..=>C I$,/6(=( 3=.6/=)>7 prefix meaning 6>C=) I J$(($. K%.))3L %+6,2=) I 6+9 $8;6>(=)> IK6L$9=6 K:=/2)*/L %.))3 I,5/)(=( 2=C2 >*9%$+ IC$> ;+)3*,=>C I=/=( =>M.6996/=)> I9$C6.5 $>.6+C$9$>/ )=3 +$($9%.$ %+635 I (.): ,6+3=) I 2$6+/ 35( I ;6=>M*.7 6%3)9=>6. $,/) I )*/(=3$ $3$9 I (:$..=>C KM.*=3L $+5/2+) I +$3 2$;6/) .=J$+ I)=3 I)96 /*9)+ I)(=( 6%>)+96. ,)>3=/=)> , I;6/25 3=($6($ I;$>=6 3$,+$6($ I;26C=6 $6/=>C 2$;6/) I =>/$+ I %$/:$$> .$*@) I :2=/$ 96,+) I .6+C$ >$;2+) I @=3>$5 ;6> I 6.. ;$+= I 6+)*>3 I;2)%=6 M$6+ I;/)(=( ;+).6;($7 M6..=>C I(,.$+)(=( 26+3$>=>C I(/6(=( (/);;6C$ I(;6(9 =>J).*>/6+5 , ontraction ;$+= ;2.$% I J$=> ;>$*9) I .*>C N).5 I 96>5 /6,25 I +6;=3 /2+)9%) I ,.)/
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O P.))3 4 P.))3 =( 6 connective tissue P.))3 =( 6 Q .=R*=3 96/+=8 K;.6(96L Q ,$..( K$<C<7 'PA7 #PAL Q ,$.. M+6C9$>/( K;.6/$.$/(L 'HR @ \ !B1;9<*. !)5A0)>90;J ?5;>.1 X*>0) :5.-?0 ]&^ F581 X09EB> K/EM ' R @ PH' @ AI ] &6P
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S T*>,/=)>( )M %.))3 B / 4 B+6>(;)+/ Q C6($(7 >*/+=$>/(7 :6(/$(7 (=C>6.=>C 9).$,*.$( 4 '$C*.6/=)> '$C*.6/=)> Q ;? KUH<EL7 )(9).6+=/57 /$9;$+6/*+$ KUDOVAL7 M.*=3 .)(( 6/ (=/$ )M =>W*+5< 4 N+)/$,/=)> Q =9;)+/6>/ ,)9;)>$>/ )M =99*>$ (5(/$9
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!X -/+*,/*+$ )M P.))3 4 Plasma KEGIGDYL Q .=R*=3 ;6+/ )M %.))3 4 Formed Elements KDHIFEYL Q ,$..( K'PA7 #PAL Q ;.6/$.$/( K,$.. M+6C9$>/(L
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!" A)9;.$/$ P.))3 A)*>/ KAPAL 4 '$3 P.))3 A$..( Q >*9%$+7 (=Z$ 6>3 2$9)C.)%=> ,)>/$>/ 4 #2=/$ P.))3 A$..( Q >*9%$+ 0 /5;$( 4 N.6/$.$/( Q >*9%$+
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!E APA I '$3 P.))3 A$..( 4 '$3 ,$.. ,)*>/ EIG 9=..=)>[*\
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!F ?$96/),+=/ ?,/] EX FEY ^6.$ DH EHY T$96.$ Y :2).$ %.))3 J).*9$ ,)>/+=%*/$3 %5 M)+9$3 $.$9$>/( ?,/] EXIFEY ^6.$7 DHIEHY T$96.$ A6> 6>5)>$ C*$(( :25 9$> :)*.3 26J$ 6 (.=C2/.5 2=C2$+ 2$96/),+=/_
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!G `3J6>/6C$( )M /2$ %=I,)>,6J$ (26;$ 4 .6+C$ (*+M6,$ 6+$6 /) J).*9$ +6/=) 4 6>*,.$6/$ 4 ,6> $6(=.5 (/6,@ 4 ,6> M).3 0 M.$8 ,6> M).3 0 M.$8
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!H 'PA( ,)>/6=> 2$9)C.)%=> 4 ?% K?$9)C.)%=>L !DI!O C[3\ ^6.$7 !"I!G C[3\ T$96.$ 4 ^A? K9$6> ,$.. 2$9)C.)%=>L UDX ;=,)IC[,$.. 4 ^A?A K9$6> ,$.. 2$9)C.)%=> ,)>,$>/+6/=)>L D"IDGY
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!S I0?5E.5F9+ \ NB)00 45)?; 54 IF \ _0>*. IF KIF_M B9 B 449 9> 4 Y ` YW1B0?5E.5F9+ ` (05W1B0?5E.5F9+ ` 7*)F*?9+5B0?5E.5F9+ \ #5B) 0440<> ` B9EB0) *449+9>1 45) Y % #5B) 0440<> XB0+ IF F9+8; 7Y % *+8 I a >B9; 9+>0)*<>95+ 4*<9.9>*>0; >B0 )0.0*;0 54 Y % 6 b )0.0*;0 Y % *> >9;;-0 \ I*.8*+0 c440<> I*.8*+0 c440<> 805W1E0+*>08 F.558 IF B*; * B9EB0) *449+9>1 45) 7Y % *+8 A)5>5+; >B0+ 9+ 5W1E0+*>08 F.5586 b *+8 )0?5:0 7Y % TI a
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"X .5X B0?*>5<)9> 5) 81;4-+<>95+*. IF X9.. 80<)0*;0 *F9.9>1 54 F.558 >5 5W1E0+*>0 >9;;-0 *+8 <*-;0 * 89 9 / 9 <5+89>95+ /+5X+ *; *+0?9* 6 *+0?9*; 3+;-449<90+> +-?F0) 54 C#7d; B0?5))B*E0H >B0 )0;-.> 54 F.558 .5;; A0)+9<95-;H * 8049<90+<1 54 :9>*?9+ #O% *A.*;>9<H * 89;5)80) 54 >B0 )08 F5+0 ?*))5X @5X IFH 9)5+ 8049<90+> *F+5)?*. IF >B*.*;;0?9*;H -+80)A)58-<>95+ ;9</.0H<0.. *+0?9*H A59+> ?->*>95+
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