4 54 61 56 133 132 127 131 9 7 7 7 125 235

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Unformatted text preview: Presenta;on: Vitals and Lab Tests Respiratory rate Blood pressure 12 18 Missing 18 Visit 0 Month 1 Month 2 Month 3 Pulse 82 81 Missing 92 150/80 144/80 Missing 142/84 Urine Glucose Hemogl. Bilirubin Trigly Cholest K pH Visit 0 Month 1 Month 2 Month 3 Cl 7 6 7 6 104 105 106 105 6.4 5.4 6.1 5.6 133 132 127 131 9 7 7 7 1.25 2.35 1.66 1.29 6.53 6.11 7.07 6.53 4.1 4.3 4.6 4.5 Ca 2.35 2.45 2.38 2.38 Na Phos CO2 Albumin Crea-nine 139 139 140 140 1.36 1.45 1.23 1.39 26 28 26 29 46 46 47 47 Basophils Visit 0 Month 1 Month 2 Month 3 Eosinophils Monocytes Lymphocytes Neutrophils 0.02 0.03 0.02 0.07 0.13 0.19 0.22 0.21 0.51 0.52 0.67 0.71 1.61 1.61 2.49 2.35 4.32 4.05 4.70 4.37 62 71 71 62 (BUN) 7.85 8.96 8.43 7.78 State of Progression Predic-on Six expert ALS clinicians es;mated change in ALSFRS over 9 months Clinician A B C D E F Average Score  ­3  ­3  ­4  ­5  ­6  ­11  ­5.33 Reality: The pa;ent lost 12 points Predic-on Progression: Why? Why predict rate of disease progression?   Helping clinicians •  More accurate prognosis •  Iden-fying predic-ve pa-ent characteris-cs   Which lab tests worthwhile?   Stra-fying clinical trial pa-ents •  Less variability ⇒ fewer pa-ents needed ⇒ less expensive, more interpretable clinical trials •  Recent 1000 pa-ent trial cost over $100 million •  Using our algorithm, Prize4Life es-mates a 20% reduc-on in pa-ents neede...
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