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Unformatted text preview: KS
BUT IT'S NOT!!!!! Fig. 3-3 THIS LARGE SPLOTCH IS
ACTUALLY THE NUCLEOLUS!!!
CONTAINS INFO TO MAKE
rRNA IS NEVER TRANSLATED
BUT AN IMPORTANT
COMPONENT IN RIBOSOME
PRODUCTION!!!! ACTIVE CELLS
THAT ARE MAKING LOTS OF
PROTEIN HAVE VERY ACTIVE
NUCLEOLI…!!! Fluorescent in situ Hybridization (FISH) of human chromosomes
Chromosomal “spread” (or karyotype)
from a mitotic nucleus after spreading,
photographing, & arranging the chromosomes (Fig. 3-10) Within nucleus, there's a small region for each
within the chromatin!!!!! Each one has their own "territory." Sequence of DNA is known in each of the 23 human
chromosomes. Can make RNA probe against speciﬁc region
in one of the chromosome that, when hybridized, can
ﬂuoresce in diff colors under certain wavelengths. Chromosomal territories in the nonmitotic
nucleus of a fibroblast in cell culture (Fig.
3-7b) nuclear envelop continuous with rough ER!!!
Other important nuclear components include:
(1) the double-membrane called the nuclear envelop, continuous with RER;
(2) the fibrous meshwork of the nuclear lamina (NL), consisting of
NL = "scaffolding" -- comes from word "laminated&qu...
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- Spring '14