Cells kill themselves in apoptosis by activating a

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Unformatted text preview: icide and removal caused by specific gene activity Apoptosis is rapid individualized cell death controlled by specific gene activity. Cells kill themselves in apoptosis by activating a specific genetic control pathway. Apoptosis is a highly-regulated process triggered by release of cytochrome c from mitochondria and activation of DNA endonucleases and specific proteases (called caspases) which degrade chromatin and cytoplasmic proteins, respectively. So cytoskeleton Fig. 3-19 comes apart and cell shrinks into NOTHING. Apoptotic cell loses cell junctions and chromatin condenses (pyknosis). The apoptotic nucleus and the cell shrink, forming one or many apoptotic bodies. These do not break up and release their contents, but are engulfed (phagocytosis) by other cells. Apoptosis = NORMAL. very minor, no inflammatory response, very rapid. Necrosis = WHEN CELL IS INJURED. cell proteins gets released, cell bursts open! this is BAD -- inflammatory response is stimulated. influx of WBCs… …can be a very damaging process. It is important to distinguish apoptosis from cellular necrosis, which is death due to some form of tissue injury. Necrosis results in release of cellular proteins, etc. which elicit an inflammatory response in th...
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This document was uploaded on 02/04/2014.

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