Unformatted text preview: e tissue,
which is a transient, reparative process involving a
major influx of white blood cells and consequences
that can further damage cells.
The study of such tissue changes are part of the
field of pathology where it is part of the basis for
diagnosing certain diseases such as infections . Cell proliferation is regulated by a series of
genes coding for:
• Mitogens or growth factors (proteins that specifically
• Receptors for such mitogens
• Components of intracellular signal transduction
pathways activated by mitogen/receptor complexes
• DNA-binding transcription factors specifying new
Read about this!!!!! Many such genes are “proto-oncogenes.”
They can mutate and become defective and
oncogenic, i.e. lead to unregulated proliferation,
an early step in cancerous growth. Quality control & tumor suppression
Other proteins, such as cell cycle checkpoint regulators and
p53, normally monitor cell growth and cell cycling. When protooncogenes mutate and cell cycling or other metabolic activities
can no longer be controlled, p53 and similar regulators often
induce apoptosis .
These genes code for tumor suppre...
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This document was uploaded on 02/04/2014.
- Spring '14