The study of such tissue changes are part of the

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Unformatted text preview: e tissue, which is a transient, reparative process involving a major influx of white blood cells and consequences that can further damage cells. The study of such tissue changes are part of the field of pathology where it is part of the basis for diagnosing certain diseases such as infections . Cell proliferation is regulated by a series of genes coding for: •  Mitogens or growth factors (proteins that specifically trigger mitosis) •  Receptors for such mitogens •  Components of intracellular signal transduction pathways activated by mitogen/receptor complexes •  DNA-binding transcription factors specifying new gene transcription Read about this!!!!! Many such genes are “proto-oncogenes.” They can mutate and become defective and oncogenic, i.e. lead to unregulated proliferation, an early step in cancerous growth. Quality control & tumor suppression Other proteins, such as cell cycle checkpoint regulators and p53, normally monitor cell growth and cell cycling. When protooncogenes mutate and cell cycling or other metabolic activities can no longer be controlled, p53 and similar regulators often induce apoptosis . These genes code for tumor suppre...
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