They produce cells that either become more stem cells

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Unformatted text preview: th half the DNA content). Many tissues/organs have a very slowly dividing population of cells called stem cells. They produce cells that either become more stem cells or change into progenitor cells or “transit amplifying cells” which are committed to differentiate as some specialized type of cell. Many such fully differentiated cells can no longer divide and are said to be terminally differentiated but completely functional. ex: RBC. has lost its nucleus! can't ever divide anymore. Most terminally differentiated cells gradually become senescent and are replaced during a lifetime; a few last an entire lifetime. Fig. 3-17 Terms describing various cell fates: Proliferating – state of a continuously cycling cell population seen best in stem cells and their progeny committed to differentiate: transit amplifying cells Quiescence – state of cells in G0 but capable of cycling again Differentiated – state of functionally specialized quiescent cells, which are stable but capable of dividing again Terminally differentiated – state of specialized cells that cannot re-enter cell cycle and divide Senescent – state of a functional cell no longer able to divide and losing function Apoptosis – cell su...
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This document was uploaded on 02/04/2014.

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