Unformatted text preview: (The last 3 types will be studied later.)
Cartilage and bone SUPER specialized for support. ALL of these CTs derived from mesenchyme/mesoderm in embryo!! Functions of connective tissue proper:
• Provide structural/physical support
• Serve as the site of blood vessels and a
medium for diffusion and exchange of
nutrients, metabolites, and wastes
between cells and blood vessels
• Serve as main site for immune defense
and immune protection in all organs.
• Site for the body’s storage of fat in special
cells called adipocytes.
particularly capillaries through which diffusion of nutrients/waste can occur! immune cells -- WBCs, lymphocytes -- most of their activity takes place in CT!! Most FAT stored in ADIPOSE TISSUE, a type of CT. The hallmark feature of CT proper is the large
volume of extracellular matrix (ECM) which
besides cells includes two major kinds of
1. Protein fibers, mainly of collagen or elastin
2. “Ground substance”: clear, water-rich material
through which diffusion occurs
Besides water, ECM contains PROTEIN FIBERS (IMP: COLLAGEN & ELASTIN!!!)
and a watery substance referred to as GROUND SUBSTANCE -- looks like NOTHING
in microscopy (watery, unstained region) but in fact its imp. bc most diffusion occurs here! Fibroblasts synthesize most collagen and ground
substance. They are the key cell in most types of
connective tissue. Surrounded by much ECM, fibroblasts
are long, tapering cells with elongated or ovoid nuclei.
divide slowly!! but are growing! "-blast" Fibroblasts: Most imp. component of CT proper. Fibroblasts synth. ALL
components of ECM
and secrete it OUTSIDE
OF CELL where it becomes
organized as ECM!!! LOTS of collagen here and
less ground substance!
DENSER. LOTS of watery
ground substance here! Fig. 5-3 Collagen gives tissue its tensile strength and is a main
feature of CT. With H&E staining, collagen appears as
eosinophilic bundles of fibers. Most of the cell nuclei
seen in the left figure are of fibroblasts, which produced
the eosinophilic bundles of...
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- Spring '14
- Collagen, ground substance