Unformatted text preview: branes,
thus allowing cells to adhere to the ECM. Examples:
• laminin (in all basal laminae) and tenascin
• fibronectin (can form fibrils in ground substance) mediate cell adhesion to coll. KNOW THESE
GLYCOPROTEINS. Would bind here to
glycoprotein! This dimer is
INTEGRIN. So these glycoproteins adhere to collagen, but also to INTEGRINS They mediate
interact in ECM. These ECM glycoproteins also all bind
to various integrins in cell membranes
(seen at left), thus allowing integrins to
serve as “cell adhesion molecules”
binding the cell to the ECM. The cell
cytoskeleton is also bound to integrins
and is thus attached indirectly to the
(You need not know about these interactions in
detail, but know the role of integrins in generally
linking the cytoskeleton to the ECM.) CYTOSKELETON!!!
BC OF INTEGRIN,
INDIRECTLY BOUND TO
ECM!!!! VIA GLYCOPROTIEN. Fig. 5-19 Tissue immuno-stained using antibodies against laminin, which is
distributed in the ECM around most cells and other structures.
It is present in the basal lamina and elsewhere, but not between
epithelial cells (top). Fig. 5-18b CT can exist in as various types, based mainly on the density and
regularity of collagen (Studied in lab today, see Table 5-6).
Fig. 5-21a,b,c LOOSE CT.
Lots of ground
substance. Elongated dots are
mostly ﬁbroblasts. L= loose (or areolar) CT Most of
lymphocytes. D=dense irregular CT DENSE CT. Tons of Collagen. Found in DERMIS of skin, in most
STROMA, typical "packing" material. Fig. 5-22a D dense regular CT Adipose tissue is loose CT that also contains many adipocytes (A), which are
large cells for storage of fats. They are usually “unilocular”, with a single large
lipid droplet (white fat; below left). Lipid is removed in slide processing, so most
of cell appears empty and unstained.
In specialized brown fat (right), adipocytes are “multilocular”, with many
smaller lipid droplets and many mitochondria specialized here to generate heat.
Brown fat is most abundant in neonates (and in hibernating mammals.) Fig. 6-1a Fig. 6-4a...
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- Spring '14
- Collagen, ground substance