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This dimer is integrin so these glycoproteins adhere

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Unformatted text preview: branes, thus allowing cells to adhere to the ECM. Examples: • laminin (in all basal laminae) and tenascin • fibronectin (can form fibrils in ground substance) mediate cell adhesion to coll. KNOW THESE GLYCOPROTEINS. Would bind here to glycoprotein! This dimer is INTEGRIN. So these glycoproteins adhere to collagen, but also to INTEGRINS They mediate how things interact in ECM. These ECM glycoproteins also all bind to various integrins in cell membranes (seen at left), thus allowing integrins to serve as “cell adhesion molecules” binding the cell to the ECM. The cell cytoskeleton is also bound to integrins and is thus attached indirectly to the ECM components.) (You need not know about these interactions in detail, but know the role of integrins in generally linking the cytoskeleton to the ECM.) CYTOSKELETON!!! BC OF INTEGRIN, CYTOSKELETON INDIRECTLY BOUND TO ECM!!!! VIA GLYCOPROTIEN. Fig. 5-19 Tissue immuno-stained using antibodies against laminin, which is distributed in the ECM around most cells and other structures. It is present in the basal lamina and elsewhere, but not between epithelial cells (top). Fig. 5-18b CT can exist in as various types, based mainly on the density and regularity of collagen (Studied in lab today, see Table 5-6). Fig. 5-21a,b,c LOOSE CT. Lots of ground substance. Elongated dots are mostly fibroblasts. L= loose (or areolar) CT Most of these red dots are lymphocytes. D=dense irregular CT DENSE CT. Tons of Collagen. Found in DERMIS of skin, in most STROMA, typical "packing" material. Fig. 5-22a D dense regular CT Adipose tissue is loose CT that also contains many adipocytes (A), which are large cells for storage of fats. They are usually “unilocular”, with a single large lipid droplet (white fat; below left). Lipid is removed in slide processing, so most of cell appears empty and unstained. In specialized brown fat (right), adipocytes are “multilocular”, with many smaller lipid droplets and many mitochondria specialized here to generate heat. Brown fat is most abundant in neonates (and in hibernating mammals.) Fig. 6-1a Fig. 6-4a...
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