Unformatted text preview: THER?! 1) Tight junctions (zonula
claudin and occludin bind to
actin. Two functions: to block
any flow between the cells and
to establish apical and (water)
basolateral domains in the cell
membrane (preventing free
lateral movements of membrane
components.) JUNCTIONS IN OUR
IT'S THE LOSS OF THESE
BOWELS THAT LEAD DO DIARRHEA!!!!!!! 2) Adherent junctions (zonula
adherens): cadherin These much
transmembrane proteins than tight jxn!
indirectly bind actin filaments via
catenin, vinculin and α-actinin.
cadherins larger & more abundant than claudin. ITS SUPER IMP.
TO KEEP THE
AND LATERAL SIDES
ALL DIFF!!!! DUE TO
IMP. TO KEEP THE
FOR ITS FXN! 3) Desmosomes (macula
attachment proteins (e.g.,
desmoplakin) bind IFs
(keratins), with extracellular
desmogleins as an adhesive
“plaque” between cells.
their fxn: to supplement strengthening of adherent jxns The structure of the junctions seen
here by TEM and SEM. The junctions
and the attached cytosk...
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- Spring '14
- Epithelial cells, Epithelia, basement membrane