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Two functions to block any flow between the cells and

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Unformatted text preview: THER?! 1) Tight junctions (zonula occludens): transmembrane claudin and occludin bind to actin. Two functions: to block any flow between the cells and to establish apical and (water) basolateral domains in the cell membrane (preventing free lateral movements of membrane components.) JUNCTIONS IN OUR IT'S THE LOSS OF THESE BOWELS THAT LEAD DO DIARRHEA!!!!!!! 2) Adherent junctions (zonula adherens): cadherin These much stronger transmembrane proteins than tight jxn! indirectly bind actin filaments via catenin, vinculin and α-actinin. cadherins larger & more abundant than claudin. ITS SUPER IMP. TO KEEP THE APICAL, BASAL, AND LATERAL SIDES ALL DIFF!!!! DUE TO TIGHT JUNCTIONS!!! IMP. TO KEEP THE CELL POLARIZED FOR ITS FXN! 3) Desmosomes (macula adherens): cadherin-like attachment proteins (e.g., desmoplakin) bind IFs (keratins), with extracellular desmogleins as an adhesive “plaque” between cells. their fxn: to supplement strengthening of adherent jxns The structure of the junctions seen here by TEM and SEM. The junctions and the attached cytosk...
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