Unformatted text preview: us or certain organelles). Or, if the new
proteins have specific “signal sequences”, they may bind to proteins on the ER
(right) forming the “rough ER”, where most proteins in membranes, in secretory
If ribosomes free in cytoplasm, they're making FREE
vesicles, and lysosomes are produced.
Fig. 2-9 proteins, that work in cytoskeleton, or work inside
(in cytoplasm) -- POLYSOME Polysome = 2+
ribosomes on same
mRNA nucleus…. Bound ribosomes make proteins that are
SECRETED, or become membrane proteins. Bound ribosome pdts become
sequestered in CERTERNA and then
either go into secretory vesicles or go into lysosomes If protein can't be folded
properly, its converted to
UBIQUITIN and then
transferred to a proteosome
where broken down into
AAs to be re-used. Misfolded proteins are “ubiquitinated” and directed to proteasomes for break
down back to into amino acids. CHAPERONES CONSTANTLY MAKING SURE PROTEINS GET FOLDED PROPERLY!!!! smooth ER is mostly LIPIDS. so they typically stain poorly under a microscope! RER can undergo a transition to “smooth ER” which is the site of 3 other major
activities or func...
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This document was uploaded on 02/04/2014.
- Spring '14