Exam Review - Chapter 18

3 pathways of amino acid degradation all or part of

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Unformatted text preview: ne transcarbamoylase 3. Formation of argininosuccinate through citrullyl- AMP intermediate a. Catalyzed by argininosuccinate synthetase 4. Formation of arginine from argininosuccinate a. Cleaved by argininosuccinase b. Releases fumarate, which enters citric acid cycle 5. Formation of urea a. Arginase cleaves arginine to yield urea b. Generates ornithine as well Citric Acid and Urea cycles are linked Fumarate, for example, is an intermediate in the citric acid cycle Aspartate- argininosuccinate shunt: pathways linking the citric acid cycle and urea cycles Activity of urea cycle is regulated at two levels Regulation of the rates of synthesis of the four urea cycle enzymes Synthesized at higher rates in staving animals and in animals on high protein diets On a shorter time scale, allosteric regulation of one enzyme adjusts the flux through the urea cycle Carbamoyl phosphate synthetase I...
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This note was uploaded on 02/06/2014 for the course BCHB 501 taught by Professor Jessicajones,elliottcrooke,ericgalsgow,marybethmartin during the Fall '12 term at Georgetown.

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