Exam Review - Chapter 18

In two steps o glutamate and atp react to form adp

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Unformatted text preview: ovide resonance stabilization to intermediates Glutamate is transported from cytosol into mitochondria, where it undergoes oxidative deamination catalyzed by L- glutamate dehydrogenase o can use NAD+ and NADP+ as acceptors of reducing equivalents Combined action of aminotransferase and glutamate dehydrogenase is referred to as transdeamination α- ketoglutarate formed from glutamate deamination can be used in the citric acid cycle and for glucose synthesis Glutamine transports ammonia in the bloodstream Free ammonia produced in tissues is combined with glutamate to yield glutamine through glutamine synthetase requires ATP and occurs in two steps o glutamate and ATP react to form ADP and γ- glutamyl phosphate intermediate, which reacts with ammonia to produce glutamine and inorganic phosphate Glutamine is a nontoxic transport form of ammonia o Serves as...
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