Exam Review - Chapter 21

Exam Review Chapter 21

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Unformatted text preview: ce Fatty acid synthesis takes pace in the cytosol for many organisms but in the chloroplasts for plants • Fatty acid synthase complex is found exclusively in the cytosol o Segregates synthetic processes from degradative processes • Fatty acid synthesis occurs not in the cytosol but in the chloroplasts, where NADPH is produced In nonphotosynthetic eukaryotes, nearly all acetyl- CoA is formed in the mitochondria from pyruvate oxidation and from the catabolism of carbon skeletons of amino acids • Mitochondrial inner membrane is impermeable to acetyl- CoA o Requires the transfer of acetyl group equivalents across the membrane o Acetyl- CoA in the mitochondria reacts with oxaloacetate to form citrate Reaction is catalyzed by citrate synthase o Citrate passes through the inner membrane on the citrate transporter o Citrate cleavage occurs through citrate lyase, which regenerates acetyl- CoA and oxaloacetate Oxaloacetate cannot return to the matrix. So it is converted to malate by malate dehydrogenase, and can return through the malate- α- ketoglutarate transporter in exchange for citrate Malate is reoxidize dot oxaloacetate to complete the cycle o...
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This note was uploaded on 02/06/2014 for the course BCHB 501 taught by Professor Jessicajones,elliottcrooke,ericgalsgow,marybethmartin during the Fall '12 term at Georgetown.

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