Exam Review - Chapter 14

Glucose 6 phosphate is converted to fructose 6

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Unformatted text preview: required 1. Glucose is phosphorylated at C- 6 by hexokinase to yield glucose 6- phosphate a. Reaction is irreversible b. Requires Mg2+ for its activity to shield the negative charges of the phosphoryl groups in ATP 2. Glucose 6- phosphate is converted to fructose 6- phosphate by phosphohexose isomerase a. Frees hydroxyl group on C- 1 for phosphorylation 3. Fructose 6- phosphate phosphorylates to fructose 1,6- bisphosphate by phosphofructokinase- 1 (PFK- 1) a. Reaction is irreversible b. Activity of PFK- 1 is increased whenever the cell’s ATP supply is low 4. Fructose 1,6- bisphosphate is split into glyceraldehyde 3- phosphate and dihydroxyacetone phosphate by adolase 5. Dihydroxyacetone phosphate is isomerized into glyceraldehyde 3- phosphate by triose phosphate isomerase Payoff Phase- Ne...
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This note was uploaded on 02/06/2014 for the course BCHB 501 taught by Professor Jessicajones,elliottcrooke,ericgalsgow,marybethmartin during the Fall '12 term at Georgetown.

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