Exam Review - Chapter 5

Due to the alignment of the atoms adult hemoglobin

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Unformatted text preview: Θ = fraction of occupied binding sites = binding sites occupied/total binding sites = [PL]/([PL]+[P]) Kd is the dissociation constant, or the reciprocal of Ka Kd = [P][L]/[PL] = kd/ka Θ= [L] / [L] + Kd Protein structure affects how ligands bind CO has a much lower dissociation constant than O2 CO has a higher affinity to heme Possibly due to the alignment of the atoms Adult hemoglobin contains four subunits that contain four heme groups Contains two types of globin, two alpha and two beta chains Hemoglobin and myoglobin are structurally similar Erythrocytes are small and are formed from hemocytoblasts Hemocytoblasts: precursor stem cells The stem cell produces daughter cells that form large amounts of hemoglobin and hen lose their intracellular organelles Hemoglobin undergoes structural change on binding oxygen from T state to the R state Oxygen has a higher affinity for the R state; but the T state is more stable when oxygen is not present T state is stabilized by a greater number of ion pairs, but binding of hemoglobin subunit in the state triggers a change in conformation to the R stat...
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This note was uploaded on 02/06/2014 for the course BCHB 501 taught by Professor Jessicajones,elliottcrooke,ericgalsgow,marybethmartin during the Fall '12 term at Georgetown.

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