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Exam Review - Chapter 5

Segments in proximity to relatively unstable segments

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Unformatted text preview: e Alpha/Beta subunits slide past each other, narrowing the pocket Allosteric protein: one in which the binding of a ligand to one site affects the binding properties of another site of the same protein Hypothesiszed that binding of one O2 molecule to the subunit causes conformation changes that are communicated to adjacent subunits, making it easier for O2 subunits to bind Homotropic: when the normal ligand and modulator are identical Heterotropic: when the normal ligand and the modulator are different Cooperative conformational changes depend on variations in structural stability of different parts of a protein Binding sites of an allosteric protein typically consist of stable segments in proximity to relatively unstable segments, with the latter capable of frequent changes For a protein with n binding sites, the equilibrium becomes P + nL PLn Log (Θ/1- Θ) = n log [L] – log Kd nH = 1, ligand binding is not cooperative nH > 1, ligand binding is positively cooperative nH < 1, ligand binding is negatively cooperative 5.2 – Complementary Interactions between Proteins and Ligands: Th...
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