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Exam Review - Chapter 12

Epinephrine binds to its b adrenergic receptor 2

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Unformatted text preview: closely associated with guanosine nucleotide- binding proteins (G protein) family Has 7 transmembrane helical segments G protein that cycles between active and inactive G protein is heterotrimeric Effector enzyme Activated enzyme generates second messenger that affects downstream targets Ex: Adrenergic receptors (α1 α2 β1 β2) Agonists: structural analogs that bind to a receptor and mimic the effects of its natural ligand Agonists: analongs that bind to a receptors without triggering the normal effect and block the effects of agonists Β- adrenergic receptor: integral protein with 7 hydrophobic, helical regions of 20 to 28 amino acid residues that span the plasma membrane 1. Epinephrine binds to its B- adrenergic receptor 2. Hormone- receptor complex caus...
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