Exam Review - Chapter 12

Hydrolysis of gtp bound to the g catalyzed by the

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Unformatted text preview: es GDP bound to Gsα to be replaced by GTP, activating Gsα 3. Activated Gsα separates from Gsβγ, moves to adenylyl cyclase and activates it 4. Adenylyl cyclase catalyzes the formation of cAMP 5. cAMP activates PKA 6. Phosphorylation of cellular proteins by PKA causes the cellular response to epinephrine 7. cAMP is degraded by cyclic nucleotide phosphodiesterase, reversing the activation of PKA Gsα has intrinsic GTPase activity that inactivates Gsα Activation of cAMP- dependent protein kinase occurs through the binding of 2 cAMP molecules to each R subunit, which causes a conformational change that pulls the R subunits out of the catalytic subunit C Phosphorylation of the Ser or Thr residue Consensus sequence: neighboring residues needed to mark a Ser or Thr re...
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