Exam Review - Chapter 12

Insulin receptor binds insulin and undergoes

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Unformatted text preview: the specific structure in the cell Hormone- activated phospholipase C and IP3 1. Hormone binds to specific receptor 2. Occupied receptor causes GDP- GTP exchange on Gqα 3. Gqα with bound GTP moves to PLC (phospholipase C) and activates it 4. Active PLC cleaves PIP2 to IP3 and diacylglycerol 5. IP3 binds to a specific receptor- gated Ca2+ channel, releasing Ca2+ into the cell 6. Diacylglycerol and Ca2+ activate protein kinase C at the surface of the plasma membrane 7. Phosphorylation of cellular proteins by PKC produces some of the cellular responses Ca2+ is a second messenger that may be localized in space and time Serves as a second messenger that triggers intracellular responses Calmodulin is an acidic protein with four- Ca2+ binding sites Ca2+/calmodulin- dependent protein kinases: activated by the binding of Ca2+ and then calmodul...
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