Exam Review - Chapter 12

Force resting membrane potential is closer to the e

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Unformatted text preview: SRF to stimulate the transcription and translation of a set of genes needed for cell division Insulin action on glycogen synthesis 1. Phosphorylated IRS- 1 activates PI3K by binding to its SH2 domain. PI3K converts PIP2 to PIP3 2. PKB bound to PIP3 is phosphorylated by PDK1. Thus activated, PKB phosphorylates GSK3 on a Ser residue, inactivating it 3. GSK3, inactivated by Phosphorylation, cannot convert glycogen synthase to its inactive form by Phosphorylation, so GS remains active 4. Synthesis of glycogen from glucose is accelerated 5. PKB stimulates movement of glucose transporter GLUT4 from internal membrane vesicles to the plasma membrane, increase the uptake of glucose JAK- STAT signaling system also involves tyrosine kinase activity Activated by association with...
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