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Unformatted text preview: omitant risk factors or diseases
(hypertension, dyslipidemia, CHD, type 2
diabetes, sleep apnea) Pharmacotherapy (continued)
Drugs should never be used alone.
Drugs should be used in combination
with diet, exercise, and behavior
modification. Weight Loss Drugs
Drug Action Adverse Effects Sibutramine* Norepinephrine,
Norepinephrine, Increase in heart
Increase (Meridia) rate and blood pressure.
rate dopamine, and
serotonin reuptake *NOTE: FDA withdrew from US market Oct. 8, 2010
(Xenical) Alli Inhibits pancreatic
decreased fat absorption
dosage of Orlistat—
~50% strength) Decrease in absorption
of fat-soluble vitamins;
soft stools and anal
same as Orlistat Weight Loss (Bariatric)Surgery
Option for limited number of patients with
clinically severe obesity.
• BMI >40 or >35 with co-morbid conditions
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- Spring '12