Unformatted text preview: s of anaemia
i Decrease in RBC formation or Hb synthesis.
ii Excessive destruction or loss of RBC. Causes of anaemia due to less
RBC formation or production A. Nutritional causes A. 1.Anaemia due to iron deficiency. 2.Anaemia due to Vitamin B12 and folic acid deficiency.
B. Failure of bone marrow to produce RBC "Aplastic anaemia"
1.Hypoplasia of the bone marrow. 2.Invasion of bone marrow by malignant cells.
3.Chronic infection. C. Decrease or absence of erythropoietin as in renal diseases. Anaemia due to excessive destruction
of RBC or excessive loss of blood
1. Excessive destruction of RBC "Hemolytic anaemia"
a. Abnormal shape of RBC – spherocytosis. b. Abnormal Hb HbS, thalassemia.
c. Deficiency of RBC enzyme G6PD deficiency d. Effect of certain drugs.
e. Invading of RBC by parasites and destruction of RBC – Malaria.
f. Autoimmune hemolytic anaemia abnormal antibodies against RBC.
g. Blood groups incompatibility "erythroblastosis fetalis“. Anaemia due to excessive
destruction of RBC or excessive
loss of blood
2. Excessive loss of bl...
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- Spring '14
- Hemoglobin, Bone marrow