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Unformatted text preview: lastic Anaemia
Megaloblastic Due to DNA abnormalities in these large RBCs, the cell membrane & cytoskeleton of these cells are not normal & this leads to: a. abnormal cell shape. b. Flimsy cell membrane which is liable for rupture (i.e. the RBCs are more fragile & lifespan of RBCs is shortened (1/3 or ½ of normal lifespan) Aplastic Anaemia:
Aplastic It is due to:
Failure of bone marrow to produce RBCs (Aplasia of bone marrow).
Reduction in the ability of the bone marrow to produce RBCs (Hypoplasia).
Aplastic anemia is either idiopathic or secondary to another factor.
Causes of secondary aplastic anaemia:
1. Bone marrow inhibition by drugs
2. Chemical like benzene toluene solvents.
4. Diseases like viral hepatitis. Aplastic Anaemia:
Aplastic Hematological picture of aplastic anaemia:
Blood film shows pancytopenia
(A decrease in all types of blood cells i.e. RBCs, WBCs & platelets). Some cases show that one type of cell is affecte...
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This document was uploaded on 02/05/2014.
- Spring '14