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Itoccursinthesettingofchronic inflammationorneoplasm

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Unformatted text preview: lastic Anaemia Megaloblastic Due to DNA abnormalities in these large RBCs, the cell membrane & cytoskeleton of these cells are not normal & this leads to: a. abnormal cell shape. b. Flimsy cell membrane which is liable for rupture (i.e. the RBCs are more fragile & lifespan of RBCs is shortened (1/3 or ½ of normal lifespan) Aplastic Anaemia: Aplastic It is due to: ­ Failure of bone marrow to produce RBCs (Aplasia of bone marrow). ­ Reduction in the ability of the bone marrow to produce RBCs (Hypoplasia). Aplastic anemia is either idiopathic or secondary to another factor. Causes of secondary aplastic anaemia: 1. Bone marrow inhibition by drugs ­ Chloramphinicol ­ Indomethacine ­ Cytotoxic drugs ­ Anticonvulsants 2. Chemical like benzene toluene solvents. 3. Radiation. 4. Diseases like viral hepatitis. Aplastic Anaemia: Aplastic Hematological picture of aplastic anaemia: ­ Blood film shows pancytopenia (A decrease in all types of blood cells i.e. RBCs, WBCs & platelets). Some cases show that one type of cell is affecte...
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