Unformatted text preview: d.nih.gov HIV-AIDS - stages
• Stage 1: Primary HIV infection // Acute
– HIV enters the body
• infects a large number of CD4+ T cells and replicates
• the blood has a high number of HIV copies (viral load)
that spread throughout the body
– seeding in various organs, particularly the lymphoid organs
(thymus, spleen, and lymph nodes)
– the virus may integrate and hide in the cell’s genetic material
(DNA) = LYSOGENY
– Shielded from the immune system, the virus lies dormant for
an extended period of time.
– up to 70 percent of HIV-infected people suffer flu-like
symptoms. HIV-AIDS - stages
– The Immune System Strikes Back
– 2- 4 weeks after exposure to the virus, the immune system
fights back with killer T cells (CD8+ T cells) and B-cellproduced antibodies.
– HIV levels in the blood are dramatically reduced
– At the same time, CD4+ T cell counts rebound
• for some people the number rises to its original level. HIV-AIDS - stages
• Stage 2: Clinical Latency (Dormancy) or...
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