Toxicity cholinergic agonists toxicity muscarinic eye

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Unformatted text preview: Side Cholinergic Agonists MUSCARINIC • G.I. – Cramps and/or diarrhea, nausea, excess salivation • Urinary urgency • Vasodilation – feeling of warmth, faintness, nausea • Sweating Toxicity: Cholinergic Agonists Toxicity: MUSCARINIC • Eye -blurred far vision, ciliary spasm • Tearing and nose running • Bronchiole constriction and hypersecretion NICOTINIC • Autonomic = Elevated BP – NOTE: Check B.P., pulse, and respiration routinely Note that the adrenal medulla Is the only nicotinic “ganglion” with Significant perfusion. Toxicity: Cholinergic Agonists Toxicity: MUSCARINIC • Eye -blurred far vision, ciliary spasm • Tearing and nose running • Bronchiole constriction and hypersecretion NICOTINIC • Autonomic = Elevated BP – NOTE: Check B.P., pulse, and respiration routinely • Voluntary muscle twitching – especially in muscles of face CNS – Contraindication/Caution: Extreme Stimulation • Dreams and nightmares • Restlessness and anxiety • Convulsions, coma, respiratory failure Therapeutic Uses Therapeutic Cholinergic Antagonists e.g. Atropine, Scopolamine • G.I. – peptic ulcer – decreasing cramps or diarrhea – acute pancreatitis • Relaxation of bladder • Ophthalmic uses (not Glaucoma) – dilatatio...
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