Central acting skeletal muscle relaxants direct

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: polarize the membrane (as does Ach) • antagonists do not decrease their effect. Skeletal Muscle Relaxants Skeletal (usually antinicotinic) • Therapeutic uses (Note: These are not chronic) – – – – facilitate surgery facilitate electroconvulsive therapy facilitate endotracheal intubation treat tetanus • Cautions – may cause respiratory paralysis – may cause cardiac collapse (antinicotinic) – interactions alter neuromuscular blocking • + with acidosis, some antibiotics (streptomycin), quinidine • - with low serum potassium – slower GI motility -better absorption of other drugs • Toxicities possible with many drugs Objective 5: Objective Discuss potential therapeutic uses, side effects, and cautions of: – central acting skeletal muscle relaxants – direct acting skeletal muscle relaxants. • NOTE: These are NOT peripheral nervous system drugs. Routes to Skeletal Routes Muscle Relaxation 1. Block motor control in CNS 2. Block neuromuscular junction (nicotinic) 3. Block skeletal muscle directly Skeletal Muscle Relaxants Skeletal Central Acting (Valium) • Action: Often a general depressant – Act in brainstem, basal ganglia, spinal cord – Unknown if effect is due to: • sedative effect alone • or true muscle relaxant properties • Therapeutic uses – acute traumatic muscle spasms--sprains and strains – some chronic skeletal disorders-- arthritis, spondylitis – diseases w/ involuntary muscular activity--CP • Side effects and cautions – sedation is a common problem – alertness? – drug interactions common - CNS depressants • (including alcohol) and w...
View Full Document

This document was uploaded on 02/07/2014.

Ask a homework question - tutors are online