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Unformatted text preview: polarize the membrane (as does Ach)
• antagonists do not decrease their effect. Skeletal Muscle Relaxants
(usually antinicotinic) • Therapeutic uses (Note: These are not chronic)
– facilitate surgery
facilitate electroconvulsive therapy
facilitate endotracheal intubation
treat tetanus • Cautions
– may cause respiratory paralysis
– may cause cardiac collapse (antinicotinic)
– interactions alter neuromuscular blocking
• + with acidosis, some antibiotics (streptomycin), quinidine
• - with low serum potassium – slower GI motility -better absorption of other drugs
• Toxicities possible with many drugs Objective 5:
Discuss potential therapeutic uses, side
effects, and cautions of:
– central acting skeletal muscle relaxants
– direct acting skeletal muscle relaxants.
• NOTE: These are NOT peripheral nervous system
drugs. Routes to Skeletal
1. Block motor control in CNS 2. Block neuromuscular junction (nicotinic) 3. Block skeletal muscle directly Skeletal Muscle Relaxants
Central Acting (Valium)
• Action: Often a general depressant
– Act in brainstem, basal ganglia, spinal cord
– Unknown if effect is due to:
• sedative effect alone
• or true muscle relaxant properties • Therapeutic uses
– acute traumatic muscle spasms--sprains and strains
– some chronic skeletal disorders-- arthritis, spondylitis
– diseases w/ involuntary muscular activity--CP • Side effects and cautions
– sedation is a common problem – alertness?
– drug interactions common - CNS depressants
• (including alcohol) and w...
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This document was uploaded on 02/07/2014.
- Spring '14